🇪🇺Europe

Medical Device Regulation in European Union

EU Medical Devices Regulation (MDR 2017/745) and IVDR 2017/746 govern medical devices across all 27 member states. Conformity is demonstrated via CE marking, involving Notified Bodies for higher-risk devices, and tracked through EUDAMED. The MDR represents a significant tightening vs. the former MDD.

FrameworkEU MDR 2017/745 / IVDR 2017/746
Classification systemClass I / Class IIa / Class IIb / Class III
Primary agencyEC – DG SANTE
RegionEurope
References tracked169
Updates this year16

Sources Tracked by Qalico

Qalico continuously monitors 169 references across guidelines, regulations, and standards for European Union.

Regulations

EU AI Act - (EU) 2024/16891 ref
EU IVDR - (EU) 2017/746 1 ref
EU MDR - (UE) 2017/745 1 ref
EUR-Lex Official Journal L2 refs

Guidelines

IMDRF — Consultations1 ref
IMDRF — Documents3 refs
MDCG Guidelines160 refs

Device Classification

Class IClass IIaClass IIbClass III

Based on 22 classification rules in Annex VIII. Class I: low risk, self-declaration (sterile/measuring variants require Notified Body). Class IIa/IIb: medium risk, Notified Body required. Class III: high risk (implantables, cardiac devices), strictest scrutiny. IVDs have separate Classes A–D under IVDR.

Official classification guidance →

Standards & Key Principles

Applicable Standards

ISO 13485:2016 (QMS)ISO 14971:2019 (Risk Management)EN 62304:2006+A1 (Software Lifecycle)EN 60601-1 (Electrical Safety)ISO 10993 series (Biocompatibility)ISO 15223 (Symbols for labeling)

Key Principles

  • General Safety and Performance Requirements (GSPR) — Annex I of MDR
  • Clinical Evaluation based on clinical evidence (Annex XIV)
  • CE marking as EU market access passport
  • UDI registration in EUDAMED for full traceability
  • Post-Market Clinical Follow-up (PMCF) as a continuous activity
  • Transparency via publicly available SSCP for Class III devices

Pre-Market Requirements

Technical Documentation (TD)

Comprehensive package covering device description, classification, design/manufacturing, GSPR compliance, risk management, and clinical evaluation. Required for all classes.

Notified Body Certification

Mandatory for Class IIa, IIb, and III. Notified Body reviews Technical Documentation and QMS (ISO 13485). Class III requires additional scrutiny procedures.

Clinical Investigation

Class III and some Class IIb implantables may require prospective clinical investigations where existing clinical data is insufficient.

CE Marking & Declaration of Conformity

Manufacturer issues Declaration of Conformity and affixes CE mark. Device registered in EUDAMED before market placement.

Post-Market Requirements

Post-Market Surveillance (PMS) Plan

Systematic procedure to collect and analyze post-market data. Required for all devices; intensity scales with risk class.

PSUR – Periodic Safety Update Report

Class IIa: at least every 2 years. Class IIb/III: annually. Must be available to the Notified Body.

PMCF – Post-Market Clinical Follow-up

Ongoing clinical data collection to confirm safety/performance and detect emerging risks. Requires PMCF Plan and Evaluation Report.

Vigilance Reporting

Serious incidents reported to competent authorities: 15 days for serious injuries, 2 days for death. FSCAs communicated via Field Safety Notices.

SSCP – Summary of Safety and Clinical Performance

Publicly available document required for Class III and Class IIb implantable devices. Updated annually.

International Recognition & Reliance

Switzerland

MedDO aligned with EU MDR; CE marking accepted with Swiss Authorized Representative requirements.

Turkey

TITCK broadly aligns with EU MDR; CE marking accepted as basis for Turkish market access.

Norway / Iceland / Liechtenstein

EEA countries fully adopt EU MDR and recognize CE marking as domestic compliance.

United Kingdom

CE marking accepted for Great Britain market until June 2030 (transition period).

Stay on top of regulatory changes in European Union

Qalico monitors publications from EC – DG SANTE in real time, surfacing updates that matter to your device category — so your team never misses a critical change.